Research Scientist, Life Sciences (Large Molecules, Antibody Design)

Job summary

Responsibilities

Anthropic's Life Sciences team is building a research group focused on biological discoveries by combining AI with hands-on biological research. We're seeking a research scientist with deep expertise in therapeutic antibodies to join the team.

• Design and engineer therapeutic antibodies and oversee programs end to end, including target and epitope selection, choice of format (IgG, Fab, scFv, VHH, bispecific)…
• Define the screening cascade for each program, from binding kinetics (SPR, BLI), epitope binning, and species cross-reactivity to cell-based functional assays and developability…
• Plan the path from lead to IND-enabling studies, including in vivo pharmacology, pharmacokinetics, toxicology, and the handoff to process development and manufacturing
• Coordinate antibody production, characterization, and in vitro and in vivo studies with external contract research organizations and academic partners
• Evaluate AI-designed antibodies, drive them to experimental readout, and feed results back to research teams

What they're looking for

• PhD in biochemistry, protein engineering, immunology, molecular biology, or a related field
• Demonstrated experience in therapeutic antibody discovery and engineering, including at least one antibody you helped take from discovery through candidate selection and…
• Working knowledge of what an antibody IND requires across pharmacology, pharmacokinetics, toxicology, and chemistry, manufacturing, and controls (CMC)
• Comfort navigating ambiguity and defining problems in a rapidly evolving research environment
• Ability to work independently while collaborating effectively across cross-functional teams, with strong written and verbal communication skills

Tech stack

• Python